Ozone Therapy · Annapolis, MD
Ozone therapy is a medical treatment that uses ozone (O3), a highly reactive form of oxygen, to stimulate the body's natural antioxidant and immune defenses. At Vital You Functional Medicine in Annapolis, MD, ozone therapy is administered by Melissa Trotman, CRNP, a Johns Hopkins-trained nurse practitioner who specializes in integrative and functional medicine.
Whether you are dealing with chronic fatigue, persistent inflammation, or immune dysfunction, ozone therapy may be a powerful addition to your care plan. Vital You proudly serves patients throughout Annapolis, Anne Arundel County, and the surrounding Maryland communities.

How It Works
Medical ozone therapy uses a concentrated form of oxygen to trigger a controlled, beneficial stress response inside the body.
When ozone is introduced, it rapidly converts into reactive oxygen species (ROS). These ROS act as signaling molecules that activate the body's own antioxidant enzymes, reduce oxidative stress, and modulate the immune system.
Oxidative therapy like ozone therapy also supports antioxidant response pathways, meaning your body becomes better equipped to fight inflammation and cellular damage long after the session ends. This is why integrative ozone therapy Maryland patients experience has lasting, cumulative benefits when used as part of a broader functional medicine plan.
The most common method used at Vital You is major autohemotherapy. During this procedure, a small amount of your blood is drawn, mixed with medical-grade ozone, and then reinfused back into your body intravenously.
This IV ozone therapy approach allows the ozone to interact directly with your blood cells, stimulating an immune response, improving mitochondrial function, and enhancing circulation, all without pharmaceuticals.
Conditions & Benefits
At Vital You, ozone therapy is used as part of an integrative care plan to support a wide range of chronic and complex health concerns.
Ozone therapy for fatigue works by improving oxygen delivery to cells and restoring mitochondrial energy production, helping patients feel more energized and mentally clear.
Ozone therapy for inflammation reduces the inflammatory signaling that underlies joint pain, autoimmune flares, and chronic illness.
Ozone therapy immune support helps recalibrate an overactive or underactive immune system, making it valuable for autoimmune conditions and frequent infections.
Ozone therapy is increasingly used in integrative protocols for tick-borne illness due to its antimicrobial and immune-modulating properties.
Ozone has demonstrated antiviral activity and is used to support recovery from chronic or recurrent viral conditions.
IV ozone therapy improves red blood cell flexibility and oxygen delivery throughout the body.
Many patients seek ozone therapy to enhance overall vitality, mental clarity, and resilience. If you are unsure whether ozone therapy is right for your specific condition, Melissa Trotman, CRNP will conduct a thorough functional medicine evaluation during your consultation.
Your Visit
Your first visit begins with a thorough health history review and consultation with Melissa Trotman, CRNP. She will assess your current symptoms, lab work, and health goals to determine whether ozone therapy is the right fit and how it fits into your broader integrative care plan.
A small volume of blood, typically 100 to 200 mL, is drawn from a vein, similar to a standard IV draw.
Medical-grade ozone (O3) is introduced into the blood in a sterile collection bag, where it mixes thoroughly and triggers the ROS response.
The ozonated blood is slowly reinfused back into your bloodstream through the same IV line. Most patients relax comfortably during this process.
There is little to no downtime. Most patients resume normal activities immediately after their session.
The clinical environment at Vital You is calm, private, and designed for therapeutic comfort. Our team monitors you throughout the entire process to ensure your safety and well-being.
Session Protocol
A typical session lasts 30 to 60 minutes. Major autohemotherapy sessions generally run 45 to 60 minutes including setup and monitoring.
Melissa typically recommends an initial series of 6 to 10 sessions, spaced one to two times per week.
After completing the initial series, many patients transition to monthly maintenance sessions to sustain their results.
Because ozone therapy protocols are individualized, your exact frequency will depend on your health history, the conditions being addressed, and how your body responds. Patients pursuing ozone therapy for fatigue or chronic inflammation often notice improvements within the first few sessions, with cumulative benefits building over time.
Is This For You?
Ozone therapy at Vital You is well-suited for adults looking for integrative, root-cause approaches to chronic or complex health conditions. You may be a strong candidate if you:
Ozone therapy may not be appropriate for everyone. Contraindications include active bleeding disorders, G6PD deficiency, hyperthyroidism, and certain cardiovascular conditions. Pregnant women should not undergo ozone infusion therapy.
During your consultation, Melissa Trotman, CRNP will review your complete health history to confirm ozone therapy is safe for you.
Why Vital You
Founded by Melissa Trotman, CRNP, a Johns Hopkins-trained nurse practitioner, Vital You takes a whole-person, root-cause approach to health that goes far beyond symptom management.
Every ozone therapy session is supervised by Melissa Trotman, CRNP, ensuring clinical precision and attentive care.
Ozone therapy is offered alongside complementary services including IV therapy, Hyperbaric Oxygen Therapy, and functional medicine evaluations, all under one roof.
We serve patients throughout Annapolis, Anne Arundel County, and surrounding Maryland communities with real clinical expertise.
Our protocols are rooted in current integrative medicine research and reflect best practices in oxidative therapy.
FAQ
Ozone therapy is a medical treatment that introduces ozone (O3) into the body to stimulate antioxidant defenses, reduce inflammation, and support immune function. The most common form, major autohemotherapy, involves drawing blood, infusing it with ozone, and reinfusing it intravenously.
When administered by a qualified practitioner like Melissa Trotman, CRNP, ozone therapy is considered safe and well-tolerated. At Vital You, every session is medically supervised and preceded by a thorough health review to screen for contraindications.
Most patients begin with a series of 6 to 10 sessions spaced one to two times per week. Maintenance sessions are recommended monthly thereafter. Your exact plan depends on your health goals and response to treatment, and Melissa will guide you through a recommendation.
Ozone therapy is generally not covered by traditional health insurance, as it is considered an integrative or alternative therapy. Vital You offers transparent pricing and can discuss membership and payment options during your consultation.
IV therapy delivers vitamins, minerals, and nutrients directly into the bloodstream. Ozone infusion therapy, specifically MAH, uses ozone-treated blood to trigger immune modulation and antioxidant responses. At Vital You, these two therapies are often combined as part of a comprehensive integrative care plan.
Ozone therapy is not recommended for people with G6PD deficiency, active bleeding disorders, hyperthyroidism, certain heart conditions, or those who are pregnant. A full screening with Melissa Trotman, CRNP is required before your first ozone therapy session.
Ready to Start?
Melissa Trotman, CRNP will meet with you to review your health history, answer your questions, and design a care plan built around your goals. We serve patients throughout Anne Arundel County and surrounding Maryland communities.
Getting started is simple. Begin with a Discovery Call with Melissa, move to a Consultation, follow your personalized Six-Month Roadmap, and continue with the membership plan that best suits your needs.